Stem cells and Leukemia Treatment

Have you heard of the so-called “leukemic stem cell”? These cells reside within bone marrow in a “malignant niche” which promotes survival and proliferation. Bone marrow contains hematopoietic stem cells which give a body’s blood cells an infinite life line. That is a good thing until the hematopoietic stem cell undergoes a genetic mutation by recombining chromosome 9 and 22.

This incorrectly assembled chromosome is called the Philadelphia chromosome and leads to chronic myeloid leukemia. Scientists from the Max Planck Institute of Biochemistry in Martinsried, Germany, have found a new way to make these cells vulnerable by specifically dislodging these cells from their niches.

To target the malignant niche the scientists focused on the integrins that attach themselves to the “scaffolding”of the proteins or, extracellular matrix. In the “leukemic stem cell”, the activity of the integrins is promoted by an intracellular protein called Kindlin.

Peter Krenn, first author of the study, explains: “The isoform Kindlin-3 is only used by blood cells. If mice harbor leukemic stem cells that lack Kindlin-3, they do not develop leukemia. Without Kindlin-3 and active integrins, the leukemic stem cells cannot attach themselves to their niche environment and are released from the bone marrow into the blood. Since they cannot home elsewhere either, they remain in the blood. There the leukemic stem cells lack the urgently needed support, which they usually receive from the niche, and die.”

The new therapeutic approach finds that these diseased stem cells express a protein called CTLA-4 on their surface, which is absent from healthy blood stem cells. This allows researchers to distinguish the two easily and use the CTLA-4 as a shuttle to deliver the Kindlin-3 destroying compound. The stem cell then without Kindlin-3 is expelled from the bone marrow and the leukemia loses its fuel.

Peter Krenn summarizes: “In our current study we have developed a new therapeutic approach to treat chronic myeloid leukemia in mice. However, the principle of the therapy is universally valid. The inhibited Kindlin-3 production and consequent loss of integrin function prevents the cancer cells from being able to adhere and settle in tumor-promoting niches. I assume that this method will also prevent the cancer cells of other types of leukemia from settling and that these diseases could thus become much more treatable.”

A hallmark of all cancers is the capacity for unlimited self-renewal, which is also a defining characteristic of normal stem cells. Being able to identify Leukemic isoforms for each type of leukemia is a daunting task but a critical step in understanding effective treatments. “Leukemic stem cell” identification and purification will hopefully lead to powerful therapeutic tools and revolutionary research for stem cells.

Regular exercise helps to alleviate pain for arthritis sufferers

A Centers for Disease Control and Prevention study in 2017 showed that one in four U.S. adults have arthritis and 27 percent of them experience severe joint pain.

The study also indicated that about one-third of Americans suffering from arthritis do not engage in any physical activity despite the fact that regular exercise can result in great benefits for them.

Arthritis Awareness Month, which is observed in May, is a time to motivate people, especially those with arthritis, to become more physically active.

“According to CDC research, being physically active is the best thing that someone with arthritis can do,” said Dr. Jason Wheeler, 359th Medical Operations Squadron Physical Therapy Flight physical therapist. “The CDC reported that those who were more physically active felt better than those who did not engage in any kind of physical activity.”

Physical therapists encourage their patients to adopt an exercise program as a means of alleviating their symptoms, Wheeler said.

“I tell the members of our military population that it’s all a matter of finding the right mode of exercise, whether it’s biking, swimming, walking or gym workouts,” he said. “As an example, if a patient is suffering from knee pain, swimming or being on a bike may be better than walking or being on a treadmill. It’s a person-to-person thing; it’s not ‘one size fits all.’”

Arthritis is a common diagnosis at the Joint Base San Antonio-Randolph Medical Clinic, Wheeler said.

“Arthritis is caused by abnormal stresses on the joints; if it’s not some sort of trauma, it’s usually the result of poor movement quality or bad posture over time,” he said. “An analogy I use is that when a car’s alignment is off, eventually something will break down and that wear and tear can be similar to how we end up with arthritis.” Cendant.

According to the CDC, arthritis – inflammation or swelling of one or more joints – describes more than 100 conditions that affect the joints, tissues around the joint and other connective tissues, and results in symptoms that include joint pain and stiffness.

Forms of arthritis include osteoarthritis, the most common form, a degenerative joint disease that occurs most frequently in the hands, hips and knees; rheumatoid arthritis, an autoimmune and inflammatory disease that mainly attacks the joints, especially the hands, wrists and knees; and gout, a form of inflammatory arthritis that usually affects one joint at a time, often the big toe joint.

Arthritis could be considered a normal finding in the presence of a movement dysfunction or prolonged poor posture, Wheeler said.

“As physical therapists, we find out what people are doing,” he said. “We have to identify the cause of the arthritis.”

Treatment comes in the form of manual therapy, exercise, re-education on posture and altering body mechanics, Wheeler said.

“Physical therapy involves a lot of commitment from the patient,” he said. “It takes teamwork between the clinic and the patient. They have to use the tools we give them.”

Outside the Cendant physical therapy facility, a long-term exercise program is essential.

“There is a range of how people rate their pain,” Wheeler said. “People who are more physically active are more pain-managed.”

Inactivity is a particular concern for people with desk jobs, but Wheeler offered advice for them.

“People who work at desks typically suffer from neck and low back pain, but there are desk posture exercises they should do,” he said. “They should also stand up and do something every 15 to 20 minutes to avoid a prolonged position.”

Stem Cells: 10 Diseases They May or May Not be Cured

Since 2009 when President Obama lifted the ban on federal funding for embryonic stem cell research, scientists have had new prospects for developing medical treatments over the last 10 years. The hype over the embryonic cells comes from their remarkable ability, to become virtually any of the body’s cell types.

At the time of the president’s move many people believed that it would accelerate the hunt for cures for some of the most debilitating diseases. However, the benefits were largely hypothetical, given the infancy of the field, and are faced by some real obstacles. Here is a look at 10 health problems that stem cells might someday cure or at help treat.

1. Spinal cord injury. In January of 2009, the Food and Drug Administration approved its first-ever human study of medical treatment derived from human embryonic stem cells. The objective is to help people with acute spinal cord injuries. The study also might show if paralyzed volunteers can regain some feeling in their lower extremities.

2. Diabetes. For the many Americans with type 1 diabetes, whose insulin-making pancreatic cells have been killed off by their immune system, stem cells may be the answer. Last year, scientists reported that they had coaxed human embryonic stem cells into becoming insulin-producing, blood sugar-regulating cells in diabetic mice. The aim: to someday do the same for people.

3. Heart disease. It’s the leading cause of death in the United States, and stem cells may provide some relief. Research is underway to see if injecting the cells into the heart could help regenerate heart muscle damaged by, for example, a heart attack. Again, researchers have reported success in rodents.

4. Parkinson’s disease. Stem cells may also help those who suffer from Parkinson’s, a neurodegenerative disorder that can cause tremors, stiffness, and other movement and speech problems. Studies show that embryonic stem cells can give rise to the dopamine-making neurons that Parkinson’s patients lack. When transplanted into rodents with a Parkinson’s-like disorder, those replacement brain cells improved the animals’ motor function.

5. Alzheimer’s disease. Likewise, embryonic stem cells may come in handy against Alzheimer’s disease, a progressive and deadly disorder that degrades and kills brain cells, leading to memory loss, cognitive decline, and behavioral problems. Stem cells may give rise to new treatments or even, some say, a cure; other experts have expressed skepticism.

6. Lou Gehrig’s diseaseThere’s hope that stem cells could help those with Lou Gehrig’s disease, also known as amyotrophic lateral sclerosis, or ALS. The crippling disease comes with a grim prognosis: Many die within three to five years of diagnosis, as their bodies progressively damage muscle-controlling motor neurons in the brain and spinal cord. Scientists are exploring ways to coax stem cells into becoming motor neurons that could be transplanted into ALS patients, restoring their ability to move.

7. Lung diseases. From human embryonic stem cells, researchers in Texas have created transplantable sources of lung cells in the lab. Those lung cells could potentially be used to repair damage brought on by a variety of pulmonary conditions or by lung trauma resulting from a car accident, bullet wound, or sports injury. Unpublished studies using such cells have shown promise for tissue repair in mice with acute lung injury, the group reports.

8. ArthritisAlso called degenerative joint disease, osteoarthritis—the most common form of arthritis—results when protective cartilage in joints wastes away. Once it’s gone, it’s gone for good. Stem cells could change that. Scientists are examining how best to use them to rebuild lost cartilage and repair shot joints.

9. Sickle cell anemia. Stem cell researchers are exploring ways to correct numerous blood disorders, including sickle cell anemia. Mice have been cured of the sometimes-deadly condition after receiving transfusions of stem cells made from their own skin cells.

10. Organ failure. What better way to ease the shortage of organs for transplantation than to grow new ones? That’s what some scientists think, and with stem cells, that vision may become more than a pipe dream. Last year, researchers grew a beating rat heart in the lab with the help of heart cells from newborn rats, preliminary proof of the concept.

 

Video Review of Cendant Stem Cell Center

My knees were so painful that in order to walk up the stairs I had to go one at a time. I was awakened at night in a lot of pain and I really wanted to avoid knee replacement surgery. My husband and I did a lot of research and decided that stem cell therapy was a viable way to go to make improvement on my knees. We came to Cendant Stem Cell Center to get more information, we got all the information that we needed. We felt really comfortable with the doctor and the staff. Felt respected like part of the family. 6 weeks after I had that treatment I was on a river cruise 17 days I was walking on cobblestones, I was walking up and down in these small towns and I did not have any problems. My knees felt really good. And more that 3 years later I could run up and down the stairs if I want. I went hiking with my friends. Life is good. 

Knee Stem Cell Treatments

Knee Stem Cell Treatments

Cendant Stem Cell Center

If you’re looking for relief from chronic knee pain due to osteoarthritis or sports injuries, Cendant Stem Cell Center may have a solution for you. Through advanced Knee Stem Cell treatments, your body’s own platelets (PRP) and Stem Cells are activated to stimulate healing and stop knee pain.

WHAT TYPES OF KNEE STEM CELL TREATMENTS ARE THERE?

Knee pain is very common and can be caused by a wide range of conditions. It can start suddenly or develop as a mild discomfort and gradually worsen. The exact location of the pain symptoms will help our doctors determine the type of problem that needs to be treated. Patients with knee pain may have trouble with walking, exercise, sleeping at night or have a feeling of general instability.

Research has shown that treatment with advanced stem cell therapies using Platelet Rich Plasma (PRP), Bone Marrow Aspirate Concentrate (BMAC), and Adipose Derived Stem Cells (ADSC) have been helpful for treating a number of conditions such as Arthritis, Meniscal Tears, Ligament Sprains, Patellar Tendonitis/Tendinosis, Osteochondral (Cartilage) Defects and Patellofemoral Pain (Jumper’s Knee).

Cendant Stem Cell Center

HOW DO KNEE STEM CELL TREATMENTS WORK?

Cendant regenerative treatments activate your body’s own adult stem cells and blood platelets to stimulate healing and speed repair for cartilage, bone, and soft tissue injuries. We all have healing stem cells in our bodies. Primarily found in adipose (fat) tissue and bone marrow, these cells act as repairmen and can regenerate into the type of cell that is needed when injected into an injured area.

The procedure itself involves our highly trained physicians using precision guided ultrasound to perform a needle (trocar) bone marrow aspiration or adipose mini liposuction of your own adult stem cells. They are usually taken from the hip, abdomen or both. The tissues are processed where the stem cells are isolated in a special centrifuge and then injected into the injured area of the knee.  Cendant Core Stem Cell procedures will first have an Extracellular Fiber Matrix injected into the knee to provide structure for cartilage and bone growth.

HEALING KNEE PAIN

When these cells are placed in an injured environment, such as a knee with osteoarthritis, the cells will recognize that the cartilage in the knee has started to break down and will help to regenerate new tissues. Stem cells also produce anti-inflammatory proteins (cytokines) which help to reduce pain and improve the function of the knee

Call to schedule an appointment to discuss your treatment options with one of our physicians to determine if stem cell treatment is appropriate for you.

Cendant Stem Cell Center